USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: IF2A_HUMAN USC-OGP 2-DE database:  IF2A_HUMAN IF2A_HUMAN General information about the entry View entry in simple text format Entry name IF2A_HUMAN Primary accession number P05198 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Eukaryotic translation initiation factor 2 subunit 1; AltName: Full=Eukaryotic translation initiation factor 2 subunit alpha; Short=eIF-2-alpha; Short=eIF-2A; Short=eIF-2alpha;. Gene name Name=EIF2S1 Synonyms=EIF2A Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0436: pI=5.04; Mw=38579 Cross-references UniProtKB/Swiss-Prot P05198; IF2A_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name IF2A_HUMAN Primary accession number P05198 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 182) Name and origin of the protein Description RecName: Full=Eukaryotic translation initiation factor 2 subunit 1; AltName: Full=Eukaryotic translation initiation factor 2 subunit alpha; Short=eIF-2-alpha; Short=eIF-2A; Short=eIF-2alpha; Gene name Name=EIF2S1 Synonyms=EIF2A Encoded on Name=EIF2S1; Synonyms=EIF2A Keywords 3D-structure; Acetylation; Complete proteome; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome; RNA-binding; Translation regulation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J02645; AAA52373.1; -; mRNA EMBL BC002513; AAH02513.1; -; mRNA CCDS CCDS9781.1; -; . RefSeq NP_004085.1; NM_004094.4; . UniGene Hs.151777; -; . PDB 1KL9; X-ray; 1.90 A; A=2-183 PDB 1Q8K; NMR; -; A=5-303 PDBsum 1KL9; -; . PDBsum 1Q8K; -; . ProteinModelPortal P05198; -; . SMR P05198; -; . BioGrid 108285; 67; . DIP DIP-39418N; -; . IntAct P05198; 26; . MINT MINT-2983901; -; . STRING 9606.ENSP00000256383; -; . ChEMBL CHEMBL1255131; -; . iPTMnet P05198; -; . PhosphoSitePlus P05198; -; . SwissPalm P05198; -; . BioMuta EIF2S1; -; . DMDM 124200; -; . OGP P05198; -; . REPRODUCTION-2DPAGE IPI00219678; -; . EPD P05198; -; . PaxDb P05198; -; . PeptideAtlas P05198; -; . PRIDE P05198; -; . TopDownProteomics P05198; -; . DNASU 1965; -; . Ensembl ENST00000256383; ENSP00000256383; ENSG00000134001; . Ensembl ENST00000466499; ENSP00000425299; ENSG00000134001; . GeneID 1965; -; . KEGG hsa:1965; -; . CTD 1965; -; . DisGeNET 1965; -; . GeneCards EIF2S1; -; . HGNC HGNC:3265; EIF2S1; . HPA CAB011663; -; . HPA HPA064885; -; . MIM 603907; gene; . neXtProt NX_P05198; -; . OpenTargets ENSG00000134001; -; . PharmGKB PA27695; -; . eggNOG KOG2916; Eukaryota; . eggNOG COG1093; LUCA; . GeneTree ENSGT00390000007015; -; . HOGENOM HOG000199476; -; . HOVERGEN HBG001910; -; . InParanoid P05198; -; . KO K03237; -; . OMA GVFNIQM; -; . OrthoDB EOG091G07NN; -; . PhylomeDB P05198; -; . TreeFam TF101502; -; . Reactome R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression; . Reactome R-HSA-381042; PERK regulates gene expression; . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-72649; Translation initiation complex formation; . Reactome R-HSA-72695; Formation of the ternary complex; and subsequently; the 43S complex Reactome R-HSA-72702; Ribosomal scanning and start codon recognition; . Reactome R-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit; . Reactome R-HSA-72731; Recycling of eIF2:GDP; . SIGNOR P05198; -; . ChiTaRS EIF2S1; human; . EvolutionaryTrace P05198; -; . GeneWiki EIF2S1; -; . GenomeRNAi 1965; -; . PMAP-CutDB P05198; -; . PRO PR:P05198; -; . Proteomes UP000005640; Chromosome 14; . Bgee ENSG00000134001; -; . CleanEx HS_EIF2A; -; . CleanEx HS_EIF2S1; -; . ExpressionAtlas P05198; baseline and differential; . Genevisible P05198; HS; . GO GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0033290; C:eukaryotic 48S preinitiation complex; IBA:GO_Central; . GO GO:0005850; C:eukaryotic translation initiation factor 2 complex; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0097451; C:glial limiting end-foot; IEA:Ensembl; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0043614; C:multi-eIF complex; IBA:GO_Central; . GO GO:0005634; C:nucleus; IEA:Ensembl; . GO GO:0005844; C:polysome; TAS:ProtInc; . GO GO:0005840; C:ribosome; IBA:GO_Central; . GO GO:0044207; C:translation initiation ternary complex; IEA:Ensembl; . GO GO:0043022; F:ribosome binding; IDA:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0003743; F:translation initiation factor activity; IDA:UniProtKB; . GO GO:0007568; P:aging; IEA:Ensembl; . GO GO:0034198; P:cellular response to amino acid starvation; ISS:UniProtKB; . GO GO:0034605; P:cellular response to heat; IEA:Ensembl; . GO GO:0034644; P:cellular response to UV; ISS:UniProtKB; . GO GO:1905098; P:negative regulation of guanyl-nucleotide exchange factor activity; IEA:Ensembl; . GO GO:0032057; P:negative regulation of translational initiation in response to stress; ISS:UniProtKB; . GO GO:0036499; P:PERK-mediated unfolded protein response; NAS:ParkinsonsUK-UCL; . GO GO:1901216; P:positive regulation of neuron death; IMP:ParkinsonsUK-UCL; . GO GO:2000676; P:positive regulation of type B pancreatic cell apoptotic process; IEA:Ensembl; . GO GO:0046777; P:protein autophosphorylation; IEA:Ensembl; . GO GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB; . GO GO:1990737; P:response to manganese-induced endoplasmic reticulum stress; IEA:Ensembl; . GO GO:0006413; P:translational initiation; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . Gene3D 1.10.150.190; -; 1; . Gene3D 3.30.70.1130; -; 1; . InterPro IPR012340; NA-bd_OB-fold; . InterPro IPR022967; S1_dom; . InterPro IPR003029; S1_domain; . InterPro IPR024055; TIF2_asu_C; . InterPro IPR024054; TIF2_asu_middle; . InterPro IPR011488; TIF_2_asu; . PANTHER PTHR10602; PTHR10602; 1; . Pfam PF07541; EIF_2_alpha; 1; . Pfam PF00575; S1; 1; . SMART SM00316; S1; 1; . SUPFAM SSF110993; SSF110993; 1; . SUPFAM SSF116742; SSF116742; 1; . SUPFAM SSF50249; SSF50249; 1; . PROSITE PS50126; S1; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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